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J Audiol Otol > Volume 27(1); 2023 > Article
Journal of Audiology and Otology 2023;27(1):30-36.
DOI: https://doi.org/10.7874/jao.2022.00143    Published online January 10, 2023.
Changes in Coagulation Study and Risk of Developing Cholesteatoma: Is There a Link?
Joana Raquel Costa  , Ângela Reis Rego  , Teresa Soares  , Cecília Almeida e Sousa  , Miguel Bebiano Coutinho 
Department of Otorhinolaryngology-Head and Neck Surgery, Centro Hospitalar Universitário do Porto, Porto, Portugal
Correspondence  Joana Raquel Costa ,Tel: +351918109458, Fax: +351223320318, Email: joana_cccosta@hotmail.com
Submitted: March 23, 2022  Accepted after revision: October 27, 2022
Abstract
Background and Objectives
The etiopathogenesis of acquired pediatric cholesteatoma has not yet been fully clarified. Recent studies and modern technologies have led researchers to look for explanations at a molecular level. This study aims to understand if the origins of cholesteatoma could be related to dysfunctions in coagulation factors, thereby emphasizing its role in angiogenesis.
Subjects and Methods
This was a retrospective case-control study carried out at a tertiary hospital center between January 2010 and December 2020. The study included 92 children. The variables of the summary coagulation study (partial thromboplastin time, prothrombin time, and international normalized ratio) were compared among children with and without development of chronic otitis media with cholesteatoma.
Results
The cases and controls were comparable in terms of age, type, and number of times that ventilation tubes were placed. Partial thromboplastin times tended to be higher in children who developed cholesteatoma, with a statistically significant difference between the two groups in terms of normal and abnormal partial thromboplastin times (p=0.029).
Conclusions
The results of this case control study indicate that slight extension of partial thromboplastin times in the coagulation study may not meet the criteria for diagnosis of certain hematological pathologies or clinical significance, but at a molecular level may already have implications for activation of angiogenesis and other growth factors involved in the onset, growth, and expansion of acquired pediatric cholesteatoma.
Keywords: Pediatric cholesteatoma; Chronic otitis media; Coagulation factors; Ventilation tubes
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